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A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to current understanding of immunological principles. This book helps beginning students in biomedical disciplines to understand the basis of immunologic knowledge, and more advanced students to gain further insight. It also serves as a crucial reference for researchers studying the evolution of ideas and scientific methods. Among the fundamental insights covered in the book are: immunologic tolerance; interactions of lymphocytes with antigen - TCR and BCR; generation of diversity and mechanism of tolerance of T cells and B cells; the first cytokines; the concept of autoimmunity; identification of NK cells as a unique cell type; the structure of antibody molecules and identification of Fab and Fc regions; dendritic cells; and a complete review of the hypothesis-driven, controlled scientific experiments that have led to our current understanding of immunological principles. It explains the types of experiments that were performed and how the interpretation of the experiments altered the understanding of immunology. It presents concepts such as the division of lymphocytes into functionally different populations in their historical context.