Ever caught yourself screaming, "I could just kill that teacher"? What would it take to justify such antisocial behavior and weeks of detention? Especially if he's the best teacher you've ever had? Giving you an "F" on a quiz? Mispronouncing your name during roll call...again? How about blowing up the moon and threatening to do the same to Mother Earth-unless you take him out first?! Plus a reward of a cool 100 million from the Ministry of Defense! Okay, now that you're committed... How are you going to pull this off? What does your pathetic class of misfits have in their arsenal to combat Teach's alien technology, bizarre powers and...tentacles?! The students of 3-E turn a surplus of eggs to good use-in pursuit of their usual goal. Karasuma teaches them the art of parkour while Koro Sensei teaches them the game of cops and robbers.
Then, someone is stealing lingerie, and naturally Koro Sensei is the prime suspect! But is he being framed...and if so, by whom? Lastly, biologically modified Itona discovers that sometimes tentacles can be a burden rather than a gift. He puts everything he's got into his latest assassination attempt on Koro Sensei...but who will save Itona from himself?!