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Biological data are often characterized as having large volumes, complex structures, high dimensionality, evolving biological concepts, and insufficient data modeling practices. These characteristics require database researchers and developers to make many special considerations while developing biological databases and database systems. They also have made biological data management and knowledge discovery in databases challenging. This book will give a detailed overview of the biomedical data integration and interoperation using ontologies and provide methodologies to help solve problems in Biological Data and Information Access and Retrieval.