Thanks to a presidential pardon, the Sisterhood can put their fugitive days behind them and resume their lives in peace. Still, all the women admit that lately things are a little too calm and peaceful. Meeting up for the first time in months to celebrate Kathryn's birthday - in the City of Sin, no less - seems like the perfect antidote. But before they can kick up their heels something too big to pass up is dropped into their laps. The time has come to deal with Enemy Number 1, aka, Hank Jellicoe. Wanted by the FBI, the CIA, and Homeland Security for starters, President Connor, herself, has run out of patience with their lack of results. Only the Sisterhood, with their special blend of guts, imagination, and friends in all places are capable of pulling off the impossible - of hunting down this monster and taking him out once and for all.