DNA Conjugates and Sensors (BOK)

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Applications of nucleic acids have developed recently to provide solutions for biosensors, diagnostic tools and as platforms for the assembly of complex structures. These developments have been possible as their base sequence can be used to assemble precise structures following simple and predictable rules. Self-assembled DNA can then be amplified using polymerase chain reaction (PCR) and this ultimately enables the preparation of synthetic nucleic acids. Their use as molecular tools or DNA-conjugates has recently been enhanced by the addition of other groups including enzymes, fluorophores and small molecules. Written by leaders in the field, this volume describes the preparation and application of these DNA-conjugates. Several have been used as sensors (aptamers, riboswitches and nanostructures) based on the ability of nucleic acids to adopt specific structures in the presence of ligands, whilst others link reporter groups such as proteins or fluorophores to RNA or DNA for detection, single molecule studies, and increasing the sensitivity of PCR. The book will interest researchers in areas related to analytical chemistry, chemical biology, medicinal chemistry, molecular pharmacology, and structural and molecular biology.


Språk Engelsk Engelsk Innbinding Innbundet
Utgitt 2012 Forlag
Royal Society Of Chemistry
ISBN 9781849734271 Antall sider 316
Dimensjoner 15,6cm x 23,4cm x 2,4cm Vekt 658 gram
Leverandør Bertram Trading Ltd Andre medvirkende Andrew Ellington, David Klenerman, Duncan Graham, K. R. Fox, Makoto Komiyama, Patrick Hrdlicka, Peter G. Stockley, Souvik Maiti, Tom Brown, Yingfu Li
Emner og form DNA & Genome, Analytical chemistry, Biosensors