Principles of Translational Science in Medicine: From Bench to Bedside (BOK)

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Despite advancements in the cloning of the human genome, biomedical innovations at patient level are rare events. Translational medicine is, however, a burgeoning science that shows potential to reverse the trend. This textbook provides a survey of translational medicine, emphasising its emerging scientific backbone, its strengths and weaknesses. It explores all aspects of preclinical and clinical issues relevant to the success of translational pharmaceutical or medical device or diagnostic innovations, including target risk assessment, biomarker evaluation, and predictivity grading for both efficacy and toxicity; early human trial designs, adequate to guide stop or go decisions on the grounds of biomarker panels; and biostatistical methods to analyze multiple readout situations and quantify risk projections. Translational Science in Medicine provides guidance to design profiling strategies for new approaches to the field. By generating dialogue about translational science Wehling explores the implications of this field on the future of patient care.


Språk Engelsk Engelsk Innbinding Innbundet
Utgitt 2009 Forlag
ISBN 9780521888691 Antall sider 404
Dimensjoner 21,5cm x 25,3cm x 2,5cm Vekt 1030 gram
Leverandør Bertram Trading Ltd Andre medvirkende Francesco M. Marincola, Martin Wehling
Emner og form Medical research

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