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"The Progress in Medicinal Chemistry" series spans a wide range of topics of interest to the drug discovery community. This particular volume touches upon the following: the Herg ion channel; fluorescence-based high throughput assay; aprepitant and neurokinin receptors; muscarinic receptor targets; gene activation pathways; malaria and antimalarial drugs; and, HIV virus mutation and new therapeutics. "Progress in Medicinal Chemistry" is available online on ScienceDirect - full-text online of volumes 41 onwards. Elsevier book series on ScienceDirect gives multiple users throughout an institution simultaneous online access to an important compliment to primary research. Digital delivery ensures users reliable, 24-hour access to the latest peer-reviewed content. The Elsevier book series are compiled and written by the most highly regarded authors in their fields and are selected from across the globe using Elsevier's extensive researcher network. This title presents the latest research in the field of drug discovery. It publishes on an annual basis to bring you the most innovative updates in medicinal chemistry.