Role of Capsaicin in Oxidative Stress and Cancer (BOK)

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This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.

Produktfakta

Språk Engelsk Engelsk Innbinding Innbundet
Utgitt 2013 Forlag
Springer
ISBN 9789400763166 Antall sider 150
Dimensjoner 15,5cm x 23,5cm x 1,3cm Vekt 450 gram
Leverandør Bertram Trading Ltd Andre medvirkende Sanjay K. Srivastava
Emner og form Pharmacology, Oncology, Pathology