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Taking examples from across the natural and social sciences, this ambitious book examines the deep-seated assumptions that underpin the discovery of knowledge, and claims that all scientific methods are delusions in pursuit of theory. Using Systems Theory, in particular the concept of self-reference, the book argues that the process of observing tricks the human mind into developing a self-consistent description of itself; and a belief in the certainty of a causal 'reality'. Our theories and ways of thinking about the world around us are, in fact, distinct from the 'reality' being observed. This fresh, audacious work makes an important contribution to the study of scientific method, and takes readers out of the comfort zone of their perceived scientific certainty.