Global threats of terrorism, drug-smuggling and other crimes have led to a significant increase in research on game theory for security. Game theory provides a sound mathematical approach to deploy limited security resources to maximize their effectiveness. A typical approach is to randomize security schedules to avoid predictability, with the randomization using artificial intelligence techniques to take into account the importance of different targets and potential adversary reactions. This book distills the forefront of this research to provide the first and only study of long-term deployed applications of game theory for security for key organizations such as the Los Angeles International Airport police and the US Federal Air Marshals Service. The author and his research group draw from their extensive experience working with security officials to intelligently allocate limited security resources to protect targets, outlining the applications of these algorithms in research and the real world.