The Queen of H.I.V.E.(Holistically Integrated Viral Equality) has placed the telepathic Dr. Hector Hammond's thoughts deep into the recesses of Superman's mind in an effort to control the Man of Steel. The merging of Hammond and Man of Steel's minds brings about vivid hallucinations that cause Superman to experience different realities and view longtime allies as potential threats. With the Man of Steel unable to tell what is real and what is a hallucination, it is up to Orion of the New Gods and Wonder Woman to release H.I.V.E.'s grip on Superman and save the universe from succumbing to power of the H.I.V.E. It collects Superman numbered 18-24 and Superman Annual numbered 2.