The Nature of the Hydrogen Bond: Outline of a Comprehensive Hydrogen Bond Theory (BOK)

Gastone Gilli, Paola Gilli

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Hydrogen bond (H-bond) effects are known: it makes sea water liquid, joins cellulose microfibrils in trees, shapes DNA into genes and polypeptide chains into wool, hair, muscles or enzymes. Its true nature is less known and we may still wonder why O-H...O bond energies range from less than 1 to more than 30 kcal/mol without apparent reason. This H-bond puzzle is re-examined here from its very beginning on the ground of an inclusive compilation of experimental H-bond energies and geometries. New concepts emerge from this analysis: new classes of systematically strong H-bonds (CAHBs and RAHBs: charge- and resonance-assisted H-bonds); full H-bond classification in six classes (the six chemical leitmotifs); and assessment of the covalent nature of strong H-bonds. This leads to three distinct but inter-consistent models able to rationalize the H-bond and predict its strength, based on classical VB theory, matching of donor-acceptor acid-base parameters (PA or pKa), or shape of the H-bond proton-transfer pathway. Applications survey a number of systems where strong H-bonds play an important functional role, namely drug-receptor binding, enzymatic catalysis, ion-transport through cell membranes, crystal design and molecular mechanisms of functional materials.


Språk Engelsk Engelsk Innbinding Heftet
Utgitt 2013 Forfatter Gastone Gilli, Paola Gilli
ISBN 9780199673476
Antall sider 336 Leverandør Bertram Trading Ltd
Emner og form Pharmacology, Condensed matter physics (liquid state & solid state physics), Materials science, Physical chemistry, Molecular biology, Crystallography