Therapeutic Applications of Quadruplex Nucleic Acids (BOK)

Stephen Neidle

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The study of G-quadruplexes has emerged in recent years as an important focus of research in nucleic acids. This is now a rapidly growing area, not least because of its potential as a novel approach to cancer therapeutics, and there is much current activity on the design of quadruplex-selective small-molecule ligands and the study of their cellular effects. This timely publication gives a uniquely integrated view of quadruplex nucleic acids that will be a major resource in future drug-discovery strategies. Therapeutic Applications of Quadruplex Nucleic Acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics. Written by a world leader in this field, this book is a vital resource for researchers in medicinal chemistry, chemical biology, structural biology, drug discovery, and pharmacology in cancer and other therapeutic areas, as well as for chemists and biologists working on nucleic acids, and will be useful for both active researchers and students in these areas.

Produktfakta

Språk Engelsk Engelsk Innbinding Innbundet
Utgitt 2011 Forfatter Stephen Neidle
Forlag
ACADEMIC PRESS
ISBN 9780123751386
Antall sider 208 Dimensjoner 19,1cm x 23,5cm x 1,5cm
Vekt 567 gram Leverandør Bertram Trading Ltd
Emner og form Biochemistry

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