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An explanation of how a new view on the regulation of metabolism has been opened by the theory of metabolic control analysis. It brings together a full explanation of the new theory with an account of its experimental implementation since its origins in the 1970s. As well as noting the differences between metabolic control analysis and traditional metabolic biochemistry, the books describes the background of enzyme kinetics and metabolic investigations on which this new theory draws. A complementary title to this book is "Metabolic Regulation".